Hemophilia A is the most common of the serious hemorrhagic diseases. It is caused by a deficiency in factor VIII (anti-hemophilia factor A) and affects around 1 in 5000 male infants at birth.
The disease is inherited as an X-linked recessive trait and thus occurs in males and very rarely in homozygous females. Heterozygous females for the disease are known as carriers.
Classification of the disease is based on the severity of factor VIII deficiency, the actual cause of the hemorrhagic signs.
Hemorrhagic episodes occur primarily in joints and muscles.