Antiphospholipid syndrome (APS) is a clinical and laboratory entity consisting of persistent antibodies directed against antiphospholipid (aPL) in conjunction with recurrent venous or arterial thrombosis and obstetric signs.
Circulating lupus anticoagulant, measured by International Society on Thrombosis and Hemostasis (ISTH) criteria
Anticardiolipin antibodies (IgG or IgM), in moderate or high titre (> 40 GPL or MPL, or > 99th percentile), measured by a standardized ELISA
Anti-ß2-glycoprotein-1 antibodies (IgG or IgM), present in titre > 99th percentile, measured by a standardized ELISA
APS can occur even in the absence of any autoimmune disease, in which
case it is referred to as primary APS.
Where it arises in a patient presenting an autoimmune disease, the term
"secondary APS" is used.
If an autoimmune disease is diagnosed in a patient with primary APS, the
latter is subsequently referred to as secondary APS.