Stago’s VASP Assay Used For P2Y12 Biomarker Studies

October 1, 2010, Parsippany, NJ, USA – The VASP flow cytometry assay kit from Diagnostica Stago, Inc. (Stago), examines platelet responsiveness to specific platelet ADP receptor (P2Y12) antagonists and their in vitro effects, and may also be used as a biomarker to track hemostatic effects of P2Y12 inhibitors such as clopidogrel (PLAVIX) and other drugs targeting this receptor. Additionally, as the assay is P2Y12-specific and independent of other platelet receptors, aspirin and abciximab (ReoPro®) do not interfere. Additionally, VASP can be used to perform research on genetic causes of P2Y12 functional deficiency.
Stago’s VASP Assay Used For P2Y12 Biomarker Studies

The VASP research-use-only assay protocol is simple. Small-volume citrated whole blood samples are used to measure intracellular platelet vasodilator-stimulated phosphoprotein, and as a no-wash assay, pre-treatment steps are not required. A flow cytometer measures the sample’s phosphorylation states, and acts as a biomarker for inhibited, activated or resting platelets, with two-color results in 30 minutes. The assay’s superior stability means that samples may be analyzed up to 48 hours after collection, allowing for research or reference lab analysis away from the facility where the blood was collected. Stago’s standardized flow cytometry-based VASP assays are an alternative to traditional functional assays such as platelet aggregometry, and offer increased accessibility and sensitivity for many cellular targets. Additionally, this method offers inter-laboratory and day-to-day reproducibility as well as positive and negative threshold determinations. Stago’s VASP flow cytometry assay kit is for research use only in the U.S. and Canada, and is not for use in diagnostic procedures.

About Diagnostica Stago, Inc.Diagnostica Stago, Inc. is the exclusive provider of the Diagnostica Stago Hemostasis product lines in the United States and offers a complete system of coagulation instruments and optimized reagent kits for research as well as for routine analysis. Diagnostica Stago, Inc. is the U.S. subsidiary of Diagnostica Stago, S.A.S. France, a leader in the development and manufacture of Hemostasis products.

For more information about any Stago product or service, please call 800-222-COAG or visit our website at www.stago-us.com.PLAVIX is a registered trademark of Bristol-Meyers Squibb/Sanofi Pharmaceuticals Partnership. ReoPro is a registered trademark of Eli Lilly and Company.